Microphysiological models, also called organ-on-chip platforms, are particularly well suited to mimic the tumor microenvironment and further preclinical drug discovery. These microchip devices: Offer a bottoms-up and dissectible approach in biological system design Define tumor microenvironment and three-dimensional architecture Enable imaging and molecular analyses with high spatial resolution The in vitro microdevices can integrate the analysis of vascular and blood compartments to that of the tumor microenvironment.
Researchers from Texas A&M University have developed an ovarian tumor microenvironment (OTME) chip that enables testing of anti-cancer, vascular, and hematological drugs individually or in combination against ovarian cancer in an artificially created human-level tumor microenvironment. The OTME chip consists of a tumor cell chamber of platelet-perfused vascular…
