Patients with T2DM require lifelong insulin therapy to maintain their glycemic levels. However, gastric bypass surgery with ablation of the small intestine in such patients was shown to achieve better insulin control immediately. Now, researchers have evaluated the efficacy of an endoscopic electroporation method that ablates the mucosal layer of the duodenum along with semaglutide therapy, in improving glycemic control in 14 T2DM patients.
A 1-year follow-up of the patients revealed the following: A good glycemic control without exogenous insulin in 12 patients Reduction in HbA1c levels from 7.2% to 6.6% and plasma glucose from 158 mg/dL to 119 mg/dl An improvement in liver fat percentage by >50% A notable advantage of the electroporation technique over the existing ablative techniques is that it uses controllable electric pulses instead of heat. No adverse events were reported among…
