Can you guess the disease based on the following hints? It is a lethal myeloproliferative disease (MPD) affecting young children. It is characterized by the overproduction of myelomonocytic cells and the in vitro phenotype of hematopoietic progenitor hypersensitivity to granulocyte-macrophage colony-stimulating factor (GM-CSF). Common symptoms include anemia, bleeding/bruising, bone and joint pain, recurrent fevers/infections, abdominal pain, swelling of lymph nodes, and difficulty breathing.
Reference: Chan RJ, Cooper T, Kratz CP, Weiss B, Loh ML. Juvenile myelomonocytic leukemia: a report from the 2nd International JMML Symposium. Leuk Res. 2009 Mar;33(3):355-62.
