Colorectal cancer (CRC) is the third most common cancer, affecting mainly colon and rectum in both men and women and is the second leading cause of cancer-associated mortality. The role of the microenvironment in the initiation and progression of carcinogenesis is now realized to be of critical importance, both for enhanced understanding of fundamental cancer biology, as well as exploiting this source of relatively new knowledge for improved molecular diagnostics and therapeutics. Neither microbial genes nor microbial names cause any harm to the body, but the microbial product may do.
The presence of very active microbial biological compounds in the gut may have physiological and pathophysiological consequences for the host.-Tore Midtvedt (2008). Hence the detailed understanding of the microbial secretions (metabolites or signaling molecules) is necessary to elucidate their role…
