The research by the Wilmot Cancer Institute shows the chronic lymphocytic leukemia (CLL) patients have a higher risk of melanoma. The study published in the Leukemia Research Journal. In people with the healthy immune system, the malignant skin cell might be detected and destroyed before they became a problem.

But in CLL patient, the rate of failure of control system increases and cancer cell can grow into the tumor. They will become invasive or spread to the distant site.