Major International and Indian guidelines on hypertension recommended ARB as a 1st line treatment for hypertension. Azilsartan a long-acting and more potent ARB provides a 24-hour potent and sustained antihypertensive effect, which plays a role in its superior blood pressure lowering efficacy. Novel Sartan Azilsartan, angiotensin receptor blocker approved in US and Europe, is now available in India. Azilsartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland.
Azilsartan has more than a 10,000-fold greater affinity for the AT1 receptor than for the AT2 receptor. It also functions as an inverse agonist and inhibits AT1R signalling. Azilsartan has a unique side chain, 5-oxo-1,2,4-oxadiazole. This unique azilsartan…
