Management of hepatocellular carcinoma (HCC) requires a multidisciplinary approach. Overall, transplantation remains the best option for patients with HCC. Unfortunately, there is a limited supply of good-quality deceased donor organs.

Thus, alternative treatments, including resection, radiofrequency ablation (RFA), and, potentially, systemic therapy with medications should be used to bridge patients to transplant or to delay recurrence if possible. Early Detection of HCC: Patients with chronic viral hepatitis/liver cirrhosis caused by HBV or HCV infection are regarded as high risk for developing HCC. Regular follow-up by ultrasonography (US) every 3 months and measurements of tumor markers including alpha-fetoprotein, its activity to bind with Lens culinaris agglutinin A and protein induced by vitamin K absence or antagonist-II every month, have made it possible to detect HCC in an…