What can be done in an elderly patient who was diagnosed with chronic-phase CML that progressed to the blast phase after treatment with first and second generation Tyrosine Kinase Inhibitors (TKIs)? For the first time, a case report revealed that the induction therapy with a third-generation TKI bosutinib was successfully able to restore normal hematological response. Chronic myeloid leukemia (CML) The most critical and acute stage of chronic myeloid leukemia (CML) is Blast phase or Blast crisis. In this phase 30% blast cells fill the bone marrow and blood too.
Additional genetic changes are also common in the CML cells. In this phase, leukemia transforms into a B-cell acute lymphoblastic leukemia (B-ALL). The Ph+ chromosome is detected in 95% of CML cases, whereas it is detected in 5–49% of ALL cases. Managing the blast phase in chronic myeloid leukemia (CML) in elderly patients is…
