Synopsis Recurrent vitreous seeds contribute significantly to the failure of eye salvage in retinoblastoma. Although reports suggest the effect of periocular topotecan (POT) on retinoblastoma regression, its effect on vitreous seeds is yet to be assessed. This study is first to report the safety and efficacy of POT in vitreous seeds in retinoblastoma.
This week’s “Journal Watch” discusses a clinical trial from Indian Journal of Ophthalmology, “Periocular topotecan for vitreous seeds in retinoblastoma” Dec 2018. Authors: Purnima R Sthapit, Raksha Rao, Santosh G Honavar Key Takeaways Concurrent treatment POT with intravenous chemotherapy (IVC) could be a safe and effective approach for vitreous seeds in retinoblastoma. Objective: To assess the effectiveness of POT in the management of focal and diffuse vitreous seeds Study Type: Retrospective, noncomparative, interventional study…
