This drug acts by competitive antagonist at Benzodiazepine (BZD) receptor. Flumazenil has little clinical on Respiratory system and cardiovascular system. The drug is administered parental usually intravenously and intranasally for immediate action, The drug is only metabolized in liver (liver diseases extra care to be taken) and it's metabolites are excreted in urine. Flumazenil it's selective Benzodiazepine receptor antagonist available as injection & intranasal form It has antagonistic and antidote properties to therapeutically used Benzodiazepine, through competitive inhibition.
Doses: 0.2mg bolus, up to 3 mg to reverse BZD actions sedation, Respiratory depression. It has a rapid onset of action and it reaches its peak level of effects within a period of 5 minutes and the duration of action lasts up to 30 minutes. Different actions are reversed at different times, eg. reversal of…
