Long COVID is a public health emergency with potentially lasting health and mental health sequelae, particularly in socioeconomically marginalized groups. Hence, therapeutics targeted toward long COVID prevention are highly sought after. This Journal Watch discusses the study “ Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months (COVID-OUT): a multicentre, randomized, quadruple-blind, parallel-group, phase 3 trial ”, published in Lancet Infect Dis 2021 . 1 What was the rationale of the study?
The pathophysiology of long COVID is multifactorial, including the inflammatory cascade during acute infection and persistent viral replication. 2 In-silico modeling predicted the translation of viral proteins to be a sensitive target for inhibiting viral replication. 3 Metformin has shown suppression of protein translation and activity against the SARS-CoV-2 in…
