In recent times, the biggest challenge in cancer treatment is drug resistance, which acts as a barrier to effective cancer treatment. In such a scenario the most effective and innovative therapies also tend to fail in providing a complete and durable response rate. However, etiology of such resistance is still unknown. Factors such as irreversible genetic mutations, reversible proteomic and epigenetic mechanisms are considered to be some of the primary reasons for developing drug resistance.
Additionally, cancer treatment resistance is thought to be significant due to tumor microenvironment-mediated mechanisms and tumor heterogeneity which significantly contribute to cancer treatment resistance. Cancer is a complex phenomenon which underlies devastating clinical consequences . It is thought of as a genetic disease that evolves by clonal expansion, genetic diversification and selection .…
