Insulin resistance is traditionally associated with obesity, but lean individuals can also exhibit significant resistance due to ectopic fat, sarcopenia, and genetic predisposition. This phenotype is often under-recognized, leading to delayed diagnosis and misclassification. Tools like HOMA-IR, euglycemic clamps, and MRI-based fat quantification provide valuable insights. A deeper understanding of insulin signaling defects in muscle and liver has led to novel therapeutic targets.
Here is a quick question about lean insulin resistance! References : Diabetes, World Journal of Hepatology ##Disclaimer## The content provided on Docplexus is intended for educational purposes only. While we strive to ensure its accuracy, we make no warranties, explicit or implied, about the suitability, reliability, or adequacy of the information, including data visualization elements and graphics. We do not…
