Kidney disease due to hyperglycemia starts early in the prediabetic state itself Prediabetes might be a target for early treatment to prevent chronic kidney disease in chronic hyperglycemia. A study of 1,261 nondiabetic people aged 50 to 62 years has suggested that apparently healthy persons who have blood sugar levels higher than normal, but not yet in the diabetic range are still at risk of developing kidney damage. Such individuals are more likely to have glomerular hyperfiltration and albuminuria.
In the study, 595 people were found to have slightly abnormal blood glucose levels. And these individuals had higher probability of having glomerular hyperfiltration and albuminuria at 5-years follow-up compared to those who had normal blood sugar levels, indicating early kidney damage. Glomerular hyperfiltration (defined as GFR >90th percentile, adjusted for sex, age, weight, height, and…
