The Fetal Allograft Survival is a mysterious phenomenon, so is the Pathogenesis of Preeclampsia. An interesting hypothesis is presented for peer review and expert comments. Dynamic Graft Hypothesis tries to explain both these phenomena. This hypothesis is not based on conjecture. It has a sound logical basis. What is the Dynamic Graft hypothesis?
The Dynamic graft hypothesis tries to explain the mysterious tolerance to certain allografts and the rejection of others. According to this hypothesis, a graft that never changes the set of antigens it presents to the host is a static graft. A renal transplant, for example, presents the same set of antigens from the day 1 till it is rejected by the host. A dynamic graft, on the other hand, is capable of subtle changes in the set of antigens it presents to the host. The hypothesis postulates that: In the normal pregnancy, the fetal allograft…
