High-Intensity Training for Kynurenine Balance Schizophrenia is increasingly understood as a neuroimmune disorder, with dysregulated tryptophan–kynurenine metabolism linked to cognitive deficits, persistent symptoms, and poor psychosocial functioning. This PsyLetics pilot trial asked whether structured exercise can shift this pathway and improve clinical outcomes by randomizing 10 adults with schizophrenia or schizoaffective disorder to 8 weeks of high-intensity interval training (HIT) or low-intensity whole-body vibration (WBV) three times per week, alongside 10 age-, sex-, and BMI-matched healthy controls for baseline comparison.
Pre–post assessments included plasma kynurenine metabolites (tryptophan, kynurenine, kynurenic acid, quinolinic acid, picolinic acid, 3‑hydroxykynurenine), C‑reactive protein, body composition, 1‑repetition maximum strength, and clinician-rated scales (PANSS,…
