Fever is one of the most common reasons for pediatric consultations and is often perceived by caregivers as a harmful symptom requiring immediate reduction. As a result, aggressive fever management using antipyretics sometimes in alternating or combination regimens is widely practiced to improve child comfort and reduce parental anxiety. Clinical guidelines generally recommend antipyretic therapy primarily to relieve discomfort rather than to normalize body temperature, as fever itself is a physiological response to infection.
From an immunological perspective, fever may play a beneficial role in host defense. Elevated body temperature has been shown to enhance immune cell activity, inhibit pathogen replication, and support inflammatory signalling pathways involved in pathogen clearance. Some studies suggest that suppressing fever too aggressively may theoretically interfere with these…
