The latest WHO statistical report states that about 17.5% of adults are affected by infertility worldwide. Of the total infertility cases, 20-30% of cases are solely due to male infertility, and a further 20% are caused by male-dependent factors. Physical deformities, hormonal disorders, sexual diseases, and genetic abnormalities can cause male infertility. Genes control various physiological androgenic functions like the hypothalamus-pituitary-gonadal axis, germ cell development, differentiation, and sperm production.
As a result, genetic defects or impairments contribute to approximately 15-30% of male infertility cases. Which among the following genetic mutations is NOT associated with male infertility? 47, XXY chromosomal aberration Robertsonian translocation FMR1 gene mutation Y-chromosome microdeletion Germline mosaicism Source: WHO, The Lancet, Indian Journal of Urology,…
