Case presentation A 17-year-old female presented with progressive weight gain and amenorrhea. She had a history of irregular menstrual cycles and childhood obesity. Following menarche at age 12, she developed hirsutism with a Ferriman–Gallwey score of 14.
Initial examination Abdominal-pelvic ultrasound o Normal-sized ovaries o Multiple scattered follicular cysts, with the largest measuring 5 mm Hepatic steatosis was identified. Laboratory testing Fasting insulin levels: 84.9 µIU/mL (Reference range: 2.6–24.9 µIU/mL) Homeostasis Model Assessment of Insulin Resistance (HOMA-IR): 18.46 (Normal range: <2.0), indicating severe insulin resistance (IR) The oral Glucose Tolerance Test (OGTT) confirmed the diagnosis of IR. Weight gain history and laboratory findings The patient gained weight from 84 kg in 2017 to 118 kg in 2022 along with an increase in BMI (33.3–40.4 kg/m2) and…
