Gastroprokinetic drugs are a type of drugs which enhances the gastrointestinal motility by increasing frequencies of contractions of gastro intestinal tract but without interrupting the rhythm. Itopride is a prokinetic of benzamide derivative, acts by increasing acetylcholine concentration in gi tract by inhibiting dopamine 2 receptors and acetylcholinesterase enzyme.
Dopamine d 2 receptors first reported in 1975, these receptors distributed in central nervous system and whole gastrointestinal tract, Itopride can not penetrate the blood-brain barrier so it's effective on gi tract. Itopride is better and safer prokinetic drug than cisapride and mosapride, because cisapride is 5ht4 receptor blocker and serotonin agonist, it crosses bbs and affects potassium channels , it was first discovered in 1980 and banned in most of countries, in India it was banned in 2011 because of it side…
