Halothane Sevoflurane Chemical structure Halogenated alkane Fluorinated methyl isopropyl ether Odour Both drugs have a sweet odour Preservative for storage Yes (thymol) No Blood: gas partition coefficient High (2.4) Slower rate of induction and recovery Lower (0.69) Rapid induction and recovery MAC 0.75 (more potent) 2 (less potent) CNS effects · Hypoxic ventilator drive is severely depressed by halothane. · Blunts autoregulation and increases cerebral blood flow.
· Maximum increase in CBF among currently used volatile agents Causes an increase in CBF but to a lesser extent as compared to halothane. CVS effects Causes more severe cardiac depression · Direct myocardial depression resulting in dose dependent decrease in BP · Decreases coronary blood flow due to fall of BP · Attenuates Baroreceptor reflex thus blunting the ability…
