In a randomized controlled trial of 126 extremely preterm infants (≤28 weeks gestation) fed human milk, 800 IU/day vitamin D supplementation for the first 14 days safely raised 25-hydroxy vitamin D levels but did not reduce bronchopulmonary dysplasia (BPD) severity at 36 weeks postmenstrual age. Impulse oscillometry showed no significant improvements in airway reactance or resistance. However, a promising signal emerged for bone health, with 55% lower risk of metabolic bone disease (elevated alkaline phosphatase and hypophosphatemia) at day 28, though not statistically significant. No serious adverse events occurred, supporting early high-dose vitamin D as a safe strategy that may primarily benefit skeletal development in this high-risk population.
To read more click here ##Reference## Salas, Ariel A. et al. Early Vitamin D Supplementation in Infants Born Extremely Preterm and Fed Human…
