This is a 59-year-old female who over the past 5 months noticed a progressive thickening and darkening of the skin of her palms, dorsal hands, and ventral wrists. Physical Exam On full-body skin exam, she had rugose thickening of the palms with dermatoglyphic accentuation and a velvety appearance. She had otherwise been feeling well without weight loss, fatigue, or other systemic complaints.

She did not take medications. What can be the likely diagnosis for this patient? *This image based case is from Docplexus editorial team for educative purpose only Source: Dermatology cases for medicine