With more Indian couples seeking IVF, national fertility and embryology organizations have advised against the clinical use of a test marketed as a non-invasive method for assessing embryo genetics. The test, commonly referred to as non-invasive preimplantation genetic testing or niPGT, has been found to have limited accuracy and potential to misclassify embryos. In a first patient-focused review of its kind, the Indian Society for Assisted Reproduction, the Indian Fertility Society (IFS), and the Academy of Clinical Embryologists jointly evaluated niPGT to assess whether it is ready for clinical decision-making.
The review was led by Dr Deepak Modi at the ICMR National Institute for Research in Reproductive and Child Health (NIRRCH). Unlike standard PGT-A, which requires biopsy of trophectoderm cells, niPGT examines fragments of embryonic DNA released into the culture medium during in…
