A retrospective cohort study from the University of Miami evaluated whether the initial treatment modality influences recurrence in patients with non-metastatic leiomyosarcoma (LMS). The analysis included 151 patients who received surgery, systemic therapy, or radiation as their first treatment. Recurrence occurred in 58.1% of patients treated with surgery first, 45.8% of those receiving systemic therapy first, and 50.0% of those treated with radiation first.
Logistic regression analysis showed that initiating treatment with systemic therapy was associated with significantly lower odds of recurrence compared with the reference group (OR 0.35; 95% CI, 0.13–0.87; p=0.03). Although surgery-first (OR 2.08; p=0.08) and radiation-first (OR 1.71; p=0.54) approaches showed a trend toward higher recurrence, neither reached statistical significance. The authors suggest that treatment sequencing…
