Escherichia coli is a major cause of extraintestinal infections in all age group. However, the infection becomes more severe when patients have some underlying condition such as Diabetes Mellitus. The aim of the study was to determine whether diabetic mellitus may act as an important risk factor for the E. coli to express drug resistance property. This descriptive study was carried out in a multi‑specialty tertiary care hospital. One hundred and twenty‑seven E.
coli isolates from diabetic patients, and one hundred seventy‑three isolates from nondiabetic patients were studied. Possession drug resistance genes were determined by multiplex polymerase chain reaction (PCR). Phylogenetic analysis was performed by triplex PCR. Antibiotic sensitivity testing was performed by Kirby‑Bauer disk diffusion method. Among the study isolates from Diabetic patients maximum numbers were from phylogroup…