In the recent times, we have witnessed a 4 cases of infantile encephalopathy cases at one point of time with varied presentations. Finally MRI brain suggestive of Leigh disease (T2 hyperintensities basal ganglia). All the cases improved drastically with supplementation of thiamine, CO-Q, biotin, carnitine.
The closest differential for Leigh is acute infantile encephalitic beriberi. How to differentiate among the two, so as to make a prognosis, to have knowledge on the fate of the child and long-term viewpoint, etc. Kindly give your opinions.
