Malignancy is a well-recognized comorbidity in rheumatic diseases. The disarrayed immune system, autoreactive immune components and immunosuppressive therapy are probable causes to increased risk of cancers. Rheumatic diseases including rheumatoid arthritis, dermatomyositis, Sjogren’s syndrome and SLE have been associated with various malignancies. Most common malignancies occurring among these patients are of the lymphoid tissue. Classic symptoms of autoimmune illnesses can also occur as paraneoplastic syndromes.
Malignancies have also been suspected to be associated with immunosuppressive therapy. Mechanisms of Malignancies in Rheumatic Illness Definite mechanisms of oncogenesis in rheumatic and autoimmune diseases have not been clearly deciphered. A competent immune system is required to prevent cancer. Mutated cells that have neoplastic potential are eliminated by immunological…
