A 56-year-old female patient presented Ovarian Adenocarcinoma after the 4 th day of operation. She is suffering from 99-100 F temperatures. All the urine and blood culture done, found E.

coli in urine and sensitive with piperacillin and Amikacin. And both drugs started but until the 3 rd day of antibiotics, change there is no control in fever still fever is persisting. What could be the further management?