Knee osteoarthritis is one of the most common diseases among an elderly population that causes significant pain and decreased the quality of life. Non-steroidal Anti-inflammatory Drug (NSAID) is a choice of drug among physicians to treat knee osteoarthritis. However, there are several other topical, oral and intra-articular agents are available today but underused, and may avoid poly-pharmacy in older patients. Osteoarthritis causes the cartilage in a joint to become stiff and lose its elasticity, making it more susceptible to damage.
If the condition worsens, the bones could rub against each other, causing, even more, pain and loss of movement. The mechanisms generating pain are at least two-fold: (a) inflammatory pain triggered locally within synovium and soft tissues, and (b) neuropathic mechanisms involving both locally and centrally mediated pain pathways. In the elderly…
