Cushing’s syndrome is characterized by hypercortisolism, which generally results in anovulatory infertility. Thus, it is rarely associated with pregnancy, however, there are a few reported cases of CS in pregnancy. This article discusses diagnosis and management of CS in pregnancy. The biochemical diagnosis of CS during pregnancy is comparatively more challenging as there are certain changes in the maternal hypothalamic-pituitary-adrenal axis during pregnancy.
These include increased secretion of cortisol-binding globulin (CBG); increased concentrations of serum, salivary, and urinary free cortisol and lack of suppression of serum cortisol after dexamethasone. Also, the placenta produces corticotropin and corticotropin-releasing hormone. Clinical features of CS in pregnancy: The clinical features of CS during pregnancy include weight gain, fatigue, hypertension, hyperglycemia, and…
