On 17 th July 2022, Ghana reported its first outbreak of Marburg virus disease, after receiving a confirmation from the World Health Organization. 1,2 On 14 th February 2023, the WHO confirmed the death of nine people due to Marburg hemorrhagic fever in Equatorial Guinea, Africa. In addition, 16 more people with suspected symptoms of fever and vomiting blood were reported in Equatorial Guinea. 3 Image 1 .
History, transmission, symptoms, diagnosis, and management of Marburg infection. Since no drugs or vaccines are approved (Image 1) to treat Marburg, a few drugs, immune therapies, vaccines, and therapies with blood products are being investigated. In such an effort, a phase I clinical trial with chimpanzee adenovirus type 3 (cAd3)-vectored vaccine that encodes Marburg virus Angola glycoprotein showed promising results in adults. 4 Among 40 healthy participants, 95% displayed…
