Melatonin, secreted primarily by the pineal gland, is an endogenous hormone involved in the regulation of the circadian rhythm. It also plays a role in immunomodulation, neutralization of reactive oxygen species, and, more recently, in cancer therapy. Its effect on tumors — via the upregulation of various immune factors such as IL-4, IL-10, and IL-27 1 — makes it a promising therapeutic option in cancer management.
Cellular and molecular effect of melatonin Use of melatonin with other therapeutic regimens Various studies have reported that melatonin, as an adjuvant to standard treatment regimens, can help reduce the toxicity associated with chemotherapy 2 and also improve the efficacy of other therapeutic regimens. 3 Treatment with chemotherapy agents: 2 Supplementing anthracyclines such as doxorubicin (DOX) and its analogs with 10 mg/kg/day of melatonin improved DOX-associated…
