Few common problems associated with Acute Myeloid Leukemia (AML) in older patients (>60 yrs) are: Low complete remission rate Poor survival High mortality rate Microtransplantation (MST) has been successfully used in the management of hematological malignancies, especially in AML in the geriatric population. To compare the safety and efficacy of MST over conventional chemotherapy, a randomized clinical study was conducted. Study Summary: No.
of subjects: 58 Age: 60-88 yrs The patients were randomized to receive either chemotherapy alone or chemotherapy with G-PBSC (peripheral blood stem cells) infusion from a human leukocyte antigen (HLA) -mismatched relative. Hematopoietic recovery in the MST group was faster as compared with that in the chemotherapy group. No GVHD observed Donor microchimerism- Persistent The results demonstrated the efficacy and safety of MST in geriatric AML…
