Post-traumatic stress disorder (PTSD) is a mental health disorder that some people develop after experiencing a life-threatening event, such as a natural disaster, a car accident, or sexual assault. Such patients experience anxiety, recurring flashbacks, and negative alteration in cognition. Therapies available so far Several modes of treatment, such as antidepressants or cognitive behavioral therapy, are being widely used to treat PTSD.
However, selective serotonin reuptake inhibitors (SSRIs) are the only class of drugs that have been approved for treating PTSD. In addition, these medications have their drawbacks of delayed action, not being effective in some patients, and recurrence of symptoms (spontaneous recovery). Several studies have demonstrated the roles of glutamatergic neurons in the pathophysiology of PTSD, particularly, the effects of the N-methyl-D-aspartate receptor…
