According to a recent study, mutation or knocking down of DEAD-box helicase 3, X-linked (DDX3X), an ATP-dependent RNA helicase gene, is related to chemoresistance in non-Hodgkin lymphoma (NHL) cells. However, NHL cells with DDX3X mutation or depletion remain sensitive to inhibitors of signal transducer and activator of transcription 3 (STAT3). Non-Hodgkin lymphoma NHL is a blood cancer that includes B- and T- cell lymphomas . Every year, NHL affects more than 460,000 individuals and causes more than 240,000 deaths worldwide .
Approximately 85% of NHL cases are B-cell lymphomas. Diffuse large B-cell Lymphoma (DLBCL) is the most common B-cell lymphoma, which can be treated by a combination of chemo- and immunotherapy agents known as R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). However, a previous study demonstrated that 50% of lymphoma patients…
