The enhanced level of cross-reactivity among Flaviviruses and their co-circulation has complicated serological techniques to distinguish Zika virus (ZIKV) and dengue virus (DENV) infections. This results in an urgent need for a specific and sensitive serological test. This article outlines a novel ELISA based test that discriminates Zika virus from other Flaviviruses and aids in proper diagnosis. ZIKV, a mosquito-borne Flavivirus has become a public health risk, particularly for its association with severe congenital birth defects.
The infection is spread via the bite of infected Aedes mosquitoes or by sexual transmission. ZIKV infection during pregnancy is associated with designated congenital Zika syndrome, whereas in adults, ZIKV infection has been associated with Guillain Barré syndrome. Pitfalls of current laboratory tests: The antibody generated in response to Flavivirus…
