Non-diabetic hypoglycemia can present with vague neuroglycopenic and autonomic symptoms, making diagnosis challenging in clinical practice. This video reviews a structured approach to confirming true hypoglycemia using Whipple’s triad, differentiating endogenous and exogenous causes, interpreting key laboratory markers such as insulin, C-peptide, and beta-hydroxybutyrate, and identifying critical red flags that warrant further investigation. What is your preferred diagnostic approach when evaluating suspected non-diabetic hypoglycemia? ##Reference## Cryer, P. E. (2016). Hypoglycemia in diabetes: Pathophysiology, prevalence, and prevention. American Journal of Managed Care, 22(16 Suppl), s176–s182. Service, F.
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