Researchers from Brazil have developed an economical genosensor device that can detect an ssDNA sequence from the SARS-CoV-2 genome using four distinct principles of detection. The resultant data can then be treated with information visualization and machine learning techniques. Genosensors are nucleic acid-based biosensors that detect simple complementary RNA or DNA sequences. The study has been published in the journal Materials Chemistry Frontiers.
The genosensor device consists of a self-assembled monolayer of 11-mercaptoundecanoic acid (11-MUA), chemically bonded to glass electrodes containing gold nanoparticles or micrometric gold electrodes , onto which a layer of capture probe (cpDNA) sequence is immobilized. The immobilized cpDNA strip binds to a complementary DNA present in the liquid sample to be analyzed. This hybridization process demonstrates the presence of SARS-CoV-2 in…
