Oxygen toxicity is a complex phenomenon which could affect many organ systems. Certain are more susceptible The common manifestations of oxygen toxicity are : Pulmonary Toxicity Retrorental fibroplasia Hypoventilation Central Nervous System Toxicity. Circulatory System Pulmonary Toxicity::--- Lorraine Smith, a pathologist showed that oxygen at a partial pressure less than that required for convulsions was a lung irritant and produced inflammation, known as the "" Lorraine Smith Effect".
The toxicity depends on dose and duration of exposure to oxygen. The earliest symptom is substernal distress hi which begins ad irritation in Carina and cough. Reduction of vital capacity to Changes in capillary endothelium with an increase in its permeability which leads to accumulation of fluid in interstitial spaces and widens diffusion pathway between alveolar gas and alveolar capillary blood.…
