Dynamic Graft Hypothesis explains the various risk factors associated with preeclampsia. Nulliparity, Recurrence, Changed paternity: If a mother has suffered from preeclampsia in her earlier pregnancy, the chances of recurrence in subsequent pregnancies are high because she has developed specific immunity against the trophoblastic antigens, and the presentation of similar alloantigens in subsequent pregnancies are more likely to show recurrence of the disorder.
The mother, who has successfully tolerated the successively presented trophoblastic alloantigens in her first pregnancy, has developed specific immune tolerance to them, and the similar array of trophoblastic alloantigens presented in subsequent pregnancies is again likely to be tolerated quite well. Changed paternity, on the other hand, is a significant risk factor in a multiparous woman as she has developed specific tolerance…
