Patients On Chronic Ace Inhibitors — Have Upregulation In The Number Of Ace 2 Receptors, And Maybe Excessively Susceptible To Covid 19 Infection

Patients on chronic ACE inhibitors — have upregulation in the Number Of ACE 2 receptors, and maybe excessively susceptible to Covid 19 Infection, leading to rapid deterioration and reduced response to Treatment.. ACE inhibitors, ARBs  — though have little action on ACE 2 receptors, Chronic usage leads to increase in the number of receptors, due To upregulation.. just like .. chronic beta blocker usage leads to increase in the number of beta receptors. Moreover vitamin D regulates the Renin Angiotensin system by regulating the expression of ACE receptors . gross hypovitaminosis D leads to hypertension... in this same path .

vitamin D also suppresses Renin levels. Hypovitaminosis D leads to excessive renin .. Angiotensin. More ACE receptors .. etc. Summary : Chronic ACE inhibitor Usage + Chronic vitamin D deficiency  — leads to rampant fatal  Covid 19 and other viral infections.