1). Preconditioning Change at the biomolecular level that enables specialized tissues to tolerate a major adverse or ischaemic event better if these tissues have already been exposed to several minor adverse or ischaemic events. There are three occasions when conditioning of the myocardium can occur or could be applied. 2).
Preconditioning of the myocardium can occur before the insult, peri-conditioning can occur during the insult, and post-conditioning can occur after the insult. Regardless of the timing when the preconditioning trigger is applied, there is an early phase where cellular signalling, cascades, and amplification lead to immediate cardioprotection, and a later phase (a second window) where various triggers and mediators lead to genetic re-programming with de novo synthesis of proteins that offer sustained cardioprotection. 3). History of preconditioning research In a…
