Highlights: ·        Artificial tears are the cornerstone for treating dry eye disease (DED). They are easier to administer, available in different formulations, and have a low-risk profile.1 ·        Artificial tears made of polyethylene glycol perform better than those made of hydroxypropyl methylcellulose and carboxymethylcellulose/carmellose sodium.1 ·        Patients diagnosed with evaporative dry eye (EDE) disease benefit from liposome-infused artificial tears, especially those with higher concentrations.1