Serum Amyloid A Levels Linked to Disease Severity, Hematoma Expansion, and Prognosis in Intracerebral Hemorrhage

A single-center, real-world cohort study investigated the prognostic value of serum amyloid A (SAA) in 554 patients with intracerebral hemorrhage (ICH) and 119 healthy controls. SAA, an acute-phase inflammatory protein, was measured within 24 hours of admission and again on Days 3 and 7 after ICH onset. Patients with ICH had significantly higher serum SAA levels than healthy controls (3.1 vs. 2.4 mg/L).

Elevated SAA levels were associated with greater neurological impairment, showing positive correlations with National Institutes of Health Stroke Scale (NIHSS) scores and negative correlations with Glasgow Coma Scale (GCS) scores. Multivariate analyses identified SAA as an independent predictor of poor clinical outcomes. The study also demonstrated a significant association between SAA levels and hematoma expansion, with an area under the ROC curve of 0.694 for identifying patients at…