There are multiple treatment options available for GERD (gastroesophageal reflux disease). Cytoprotectants are one such therapy which forms a protective layer over the epithelium, shielding it from acids and enzymes.1 Sucralfate is a sucrose sulfate and aluminum hydroxide salt, which acts as a mucosal defense. It creates a functional barrier to block the dissemination of acid, pepsin, and bile acids through esophageal mucosa. Sucralfate is generally used as an add-on medication in GERD therapy.
Sucralfate's advantages are-2 Regeneration of mucosa Healing of ulcers Reducing reflux symptoms in patients with reflux esophagitis Safe option for pregnant women due to low maternal adverse events and teratogenicity In this video, Prof. Daniel Hollander discusses the cytoprotective mechanism of sucralfate in GERD. He also addresses the role of sucralfate in other diseases like renal failure,…