A prospective cohort study of 332 patients with resectable pancreatic ductal adenocarcinoma (PDAC) found that higher preoperative Grim epigenetic age acceleration (EAA) was linked to reduced overall survival (HR 1.12; 95% CI 1.02–1.27; p = 0.024), increased severe postoperative complications (OR 1.77; 95% CI 1.16–2.68; p = 0.008), and failure to complete adjuvant chemotherapy (OR 1.47; 95% CI 1.20–1.81; p < 0.0001). These results highlight Grim EAA as a potential preoperative biomarker for risk stratification in PDAC. To read more; Click Here Could epigenetic clocks transform surgical risk prediction in pancreatic cancer? ##Reference## Kollbeck S, Hansen CP, Bonde MT, Dencker EE, Burgdorf SK, Storkholm JH, Krohn PS, Johansen AZ, Millarch AS, Hillingsø JG, Christensen JF, Johansen JS, Sillesen M.
Grim Age, Grim Prognosis: Epigenetic Aging Predicts Pancreatic Surgery Risk. Ann Surg. 2025…
