The US FDA has approved desmopressin acetate oral solution for the treatment of central diabetes insipidus, to be used as antidiuretic replacement therapy in adults and pediatric patients. Clinical evidence The approval is supported by clinical studies evaluating desmopressin acetate tablets in patients with diabetes insipidus.
In these studies, treatment produced optimal antidiuretic activity, with the therapeutic effect lasting up to eight hours following administration. Dosage and administration Recommended starting dose: 0.05 mg twice daily, taken on an empty stomach, at least 1 hour before or 2 hours after meals The daily dose may be adjusted to obtain adequate antidiuretic response Monitor treatment response by measuring urine volume and osmolarity Patients transitioning from desmopressin acetate nasal spray should wait at least 12 hours after the last nasal dose before…
