A 10-year-old boy has been brought to the emergency department by his father. He was in a playground when he developed a swollen and painful right knee. History: The boy describes recurrent episodes of pain and swelling in his knees and shoulders over the last year or so. No history of trauma. He has a history of multiple blood transfusions.
On Examination: The boy has painful, tensely swollen, warm and diffusely tender knee and shoulder joints He also has multiple bruises over his legs and arms. What are the causes of this condition? What is the pathophysiology of joint involvement in this condition? Source: Cases in Rheumatology *This case is from Docplexus editorial team for educative purpose only.