The procedure of osteoblast supply during bone regeneration remained controversial. However, the latest research suggests that some osteoblast progenitor cells (OPC) that have high expression of matrix metalloproteinase-9 (MMP-9) provides osteoblast during the process of bone regeneration. In Zebrafish, when these OPCs are eliminated, the regeneration process is impaired. Source: Kazunori Ando, Eri Shibata, Stefan Hans, Michael Brand, Atsushi Kawakami.
Osteoblast Production by Reserved Progenitor Cells in Zebrafish Bone Regeneration and Maintenance. Developmental Cell, 2017. Do you think further research is justified to look for the therapeutic potential of these Osteoblast Progenitor Cells?
